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Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer
Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer
Sophia Daum
(Internal Medicine 5, Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University Innsbruck)
Lilith Decristoforo
(Internal Medicine 5, Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University Innsbruck)
Mira Mousa
(Center for Biotechnology, Khalifa University of Science and Technology)
Stefan Salcher
(Internal Medicine 5, Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University Innsbruck)
Christina Plattner
(Institute of Bioinformatics, Biocenter Medical University Innsbruck)
Baharak Hosseinkhani
(Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), VIB Center for Cancer Biology, KU Leuven, VIB)
Zlatko Trajanoski
(Institute of Bioinformatics, Biocenter Medical University Innsbruck)
Dominik Wolf
(Internal Medicine 5, Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University Innsbruck)
Peter Carmeliet
(Center for Biotechnology, Khalifa University of Science and Technology)
Andreas Pircher
(Internal Medicine 5, Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University Innsbruck)
Journal: Molecular Cancer
•
• BMC
• ISSN: 1476-4598
Abstract
Abstract The dynamic interactions between tumor endothelial cells (TECs) and the immune microenvironment play a critical role in the progression of non-small cell lung cancer (NSCLC). In general, endothelial cells exhibit diverse immunomodulatory properties, influencing immune cell recruitment, antigen presentation, and regulation of immune checkpoint expression. Understanding the multifaceted roles of TECs as well as assigning specific functional hallmarks to various TEC phenotypes offer new avenues for targeted development of therapeutic interventions, particularly in the context of advanced immunotherapy and anti-angiogenic treatments. This review provides insights into the complex interplay between TECs and the immune system in NSCLC including discussion of potential optimized therapeutic opportunities.
Sophia Daum, Lilith Decristoforo, Mira Mousa, et al. (2025). "Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer". Molecular Cancer. https://doi.org/10.1186/s12943-024-02221-6