Reset
Showing 20 of 1,492 academic articles

Anti-Amnesic Effects of Epigallocatechin Gallate on Scopolamine-Induced Learning and Memory Dysfunction in Sprague-Dawley Rats

Min-Jeong Kim, Eun-Sang Hwang, Kwan Joong Kim, Sungho Maeng et al. • Antioxidants (2021)

Epigallocatechin gallate (EGCG) is a major flavan-3-ol of green tea polyphenols that exhibits various beneficial health effects, including antioxidant, anti-bacterial, and anti-inflammatory properties. This study aimed to evaluate whether E...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox11010001

Correlation between sarcopenia and changes in oligodendrocyte lineage cells in the brains of Alzheimer's disease model mice

Lin-lin Yao, Xiao-ting Ma, Fang-bo Li, Lin-yi Zheng et al. • Experimental Gerontology (2026)

Background: Alzheimer's disease (AD) is a neurodegenerative disorder primarily characterized by cognitive dysfunction. The discovery and identification of non-cognitive symptoms in the preclinical stage hold promise for early diagnosis and ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2026.113057

Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics

Junqi Yang, Yumin Ma, Jiang Liu, Qingtian Zhu et al. • Experimental Gerontology (2024)

The aging of pancreatic beta cells is closely associated with various diseases, such as impaired glucose tolerance, yet the underlying regulatory mechanisms remain unclear. In this study, we screened young and aged mouse pancreatic beta cel...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2024.112633

Comparative efficacy of exercise interventions for cognitive health in older adults: A network meta-analysis

Jinhao Zhang, Wei Ye, Wang Li, Fan Zhang et al. • Experimental Gerontology (2025)

Background: Previous studies have consistently demonstrated that exercise mitigates cognitive decline in older adults. However, the most effective types of exercise, along with optimal frequency and duration of interventions, remain inadequ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.exger.2025.112768

Advances in the Development of PET Ligands Targeting Histone Deacetylases for the Assessment of Neurodegenerative Diseases

Tetsuro Tago, Jun Toyohara • Molecules (2018)

Epigenetic alterations of gene expression have emerged as a key factor in several neurodegenerative diseases. In particular, inhibitors targeting histone deacetylases (HDACs), which are enzymes responsible for deacetylation of histones and ...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules23020300

Tailored antihypertensive drug therapy prescribed to older women attenuates circulating levels of interleukin-6 and tumor necrosis factor-α

Toledo JO, Moraes CF, Souza VC, Tonet-Furioso AC et al. • Clinical Interventions in Aging (2015)

Juliana O Toledo,1 Clayton F Moraes,2,3 Vinícius C Souza,2 Audrey C Tonet-Furioso,2 Luís CC Afonso,4 Cláudio Córdova,3 Otávio T Nóbrega1,2 1Graduate Program in Health Sciences, 2Graduate Program in...

DOAJ Open Access (DOAJ)

The Challenge of Cultural Gerontology

Julia Twigg, Wendy E. Martin • The Gerontologist (2014)

Over the last decade, Cultural Gerontology has emerged as one of the most vibrant elements of writing about age (Twigg, J., & Martin, W. (Eds.) (2015). The Routledge handbook of cultural gerontology. London: Routledge). Reflecting the wider...

OPENALEX DOI: https://doi.org/10.1093/geront/gnu061

Influence of chemical composition and discontinuities on energy transformation and rock mass behaviour: Insights into geological dynamic

Naeem Abbas, Kegang Li, Yewuhalashet Fissha, Zemicael Gebrehiwot et al. • The Journal of Engineering (2024)

Abstract In this study, efforts were made to incorporate the influence of discontinuities and failure modes of rock into the classification of rock masses. The past tectonic activities may create microfractures in the rock body therefore th...

DOAJ Open Access (DOAJ) DOI: 10.1049/tje2.12388

Investigation of the Structural, Electrical, and Optical Properties of the Nano-Scale GZO Thin Films on Glass and Flexible Polyimide Substrates

Fang-Hsing Wang, Kun-Neng Chen, Chao-Ming Hsu, Min-Chu Liu et al. • Nanomaterials (2016)

In this study, Ga2O3-doped ZnO (GZO) thin films were deposited on glass and flexible polyimide (PI) substrates at room temperature (300 K), 373 K, and 473 K by the radio frequency (RF) magnetron sputtering method. After finding the depositi...

DOAJ Open Access (DOAJ) DOI: 10.3390/nano6050088

The electrochemical effects of pitch stabilization for supercapacitor-grade activated carbon precursors

Jeong Han Lee, Min Ju O, Yong-Mook Kang, Kwang Chul Roh • Electrochemistry Communications (2024)

Petroleum pitch (PP) is a by-product generated during the petroleum refining process, characterized by its high carbon content, tunable structure, and cost-effectiveness. These attributes have spurred extensive research into its potential a...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.elecom.2023.107638

A hybrid nanomodulator enables metabolic microenvironment remodeling for potent immunotherapy against lung adenocarcinoma

Shuping Wang, Pengcheng Chen, Xiaozhen Jing, Jinglin Zou et al. • Materials & Design (2026)

STING agonist-based immunotherapy holds considerable promise for cancer treatment, yet its efficacy against immunologically “cold” tumors such as lung adenocarcinoma (LUAD) remains markedly limited. A major obstacle lies in the highly glyco...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.matdes.2026.117182

Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

Jing Ma, Ruijuan Ma, Xueke Zeng, Liming Zhang et al. • Journal of Experimental & Clinical Cancer Research (2023)

Abstract Background Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13046-023-02768-0

Microstructure and corrosion behavior of SLM–Ti6Al4V with different fabrication angles in F−-containing solutions

Yao WANG, Xiao-ying YAN, Cheng MAN, Hong-wei ZHANG et al. • 工程科学学报 (2021)

Selective laser fusion (SLM) is an emerging 3D printing technology that can greatly shorten the processing cycle and reduce the production cost of medical implants, thus offering broad prospects for application in the biomedical field. In a...

DOAJ Open Access (DOAJ) DOI: 10.13374/j.issn2095-9389.2020.09.29.001

An In Vitro Study of Local Oxygen Therapy as Adjunctive Antimicrobial Therapeutic Option for Patients with Periodontitis

Lena Katharina Müller-Heupt, Anja Eckelt, John Eckelt, Jonathan Groß et al. • Antibiotics (2023)

Periodontitis is a common global disease caused by bacterial dysbiosis leading to tissue destruction, and it is strongly associated with anaerobic bacterial colonization. Therapeutic strategies such as oxygen therapy have been developed to ...

DOAJ Open Access (DOAJ) DOI: 10.3390/antibiotics12060990

Second hyperpolarizability of hexagonal graphene quantum dots: Effects of size and structural defects

Jiasheng Zhou, Haipeng Li, Ziqiang Yang, Zitao Zhang et al. • Carbon Trends (2021)

Graphene quantum dots (GQDs) are nanosized fragments of graphene containing a bandgap caused by edge effects and quantum confinement. These features enable GQDs to have attractive photonics applications. During the preparation of graphene n...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.cartre.2021.100054

Idiopathic pulmonary fibrosis: Addressing the current and future therapeutic advances along with the role of Sotatercept in the management of pulmonary hypertension

Dalia D. Hadi, Mohammed Dheyaa Marsool Marsool, Ali Dheyaa Marsool Marsool, Neel Vora et al. • Immunity, Inflammation and Disease (2023)

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive and debilitating lung disease characterized by irreversible scarring of the lungs. The cause of IPF is unknown, but it is thought to involve a combination of genetic a...

DOAJ Open Access (DOAJ) DOI: 10.1002/iid3.1079

Tuning the effective spin-orbit coupling in molecular semiconductors

Sam Schott, Erik R. McNellis, Christian B. Nielsen, Hung-Yang Chen et al. • Nature Communications (2017)

Organic semiconductors with long spin lifetime hold promise for future spintronics devices that can process and store information. Here, Schottet al. perform a systematic study of the strength of spin-orbit coupling and its effect on spin l...

DOAJ Open Access (DOAJ) DOI: 10.1038/ncomms15200

Highly Sensitive and Specific Detection of Influenza A Viruses Using Bimolecular Fluorescence Complementation (BiFC) Reporter System

Ui Jin Lee, Yunkwang Oh, Oh Seok Kwon, Yong-Beom Shin et al. • Biosensors (2023)

In this study, we developed a highly sensitive and specific bimolecular fluorescence complementation (BiFC)-based influenza A virus (IAV)-sensing system by combining a galactose/glucose-binding protein (GGBP) with an N-terminal large domain...

DOAJ Open Access (DOAJ) DOI: 10.3390/bios13080782

Preliminary Investigation of the Antibacterial Activity of Antitumor Drug 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide (Tirapazamine) and its Derivatives

Evelina Polmickaitė-Smirnova, Jonas Šarlauskas, Kastis Krikštopaitis, Živilė Lukšienė et al. • Applied Sciences (2020)

The antitumor drug 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ (1)) along with a number of newly synthesized tirapazamine derivatives (TPZs) bearing substitutions at the 3-amine position of TPZ (1) were estimated for their an...

DOAJ Open Access (DOAJ) DOI: 10.3390/app10124062

Development of a New 24-bit High-Performance Chipless RFID Tag for Accurate Identification in IoT Systems

Kawther Mekki, Omrane Necibi, Noureddine Boulejfen, Samia Larguech et al. • IEEE Access (2023)

Chipless RFID has the potential to bring in a paradigm change in industrial applications, notably in the world of the Internet of Things (IoT). This wireless technology permits distant identification, sensing, and tracking, giving tremendou...

DOAJ Open Access (DOAJ) DOI: 10.1109/ACCESS.2023.3337151