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Showing 4 of 24 academic articles

Flexibility-powered Pickering emulsion enhances mucus permeability to alleviate ulcerative colitis

Jiali Lv, Chen Cheng, Xinran Liu, Jinhua Song et al. • Journal of Nanobiotechnology (2025)

Abstract The physicochemical properties of oral drug delivery carriers significantly influence their interactions with the intestinal barrier, which, in turn, affect their in vivo fate and therapeutic efficacy. As a delivery system with a h...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12951-025-03829-6

Glycosylation of Epigallocatechin Gallate by Engineered Glycoside Hydrolases from <i>Talaromyces amestolkiae</i>: Potential Antiproliferative and Neuroprotective Effect of These Molecules

Juan A. Méndez-Líter, Ana Pozo-Rodríguez, Enrique Madruga, María Rubert et al. • Antioxidants (2022)

Glycoside hydrolases (GHs) are enzymes that hydrolyze glycosidic bonds, but some of them can also catalyze the synthesis of glycosides by transglycosylation. However, the yields of this reaction are generally low since the glycosides formed...

DOAJ Open Access (DOAJ) DOI: 10.3390/antiox11071325

Niclosamide nanoparticles enhance pancreatic cancer sensitivity to gemcitabine via HIF-1α inhibition

Susheel Kumar Nethi, Venugopal Gunda, Nagabhishek Sirpu Natesh, Brianna M. White et al. • iScience (2025)

Summary: Pancreatic cancer (PC) exhibits profound metabolic adaptations that support tumor progression, survival, and therapy resistance. Hypoxia-inducible factor-1α (HIF-1α) is a key regulator of these processes, promoting metabolic reprog...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.isci.2025.114088

PharmaNet Deep: Real-Time Pharmaceutical Defect Detection Using Defect-Guided Feature Fusion and Uncertainty-Driven Inspection

Ajantha Vijayakumar, Joseph Abraham Sundar Koilraj, Muthaiah Rajappa • International Journal of Computational Intelligence Systems (2025)

Abstract Oral dosage forms are the most widely employed method of drug delivery in therapeutic treatments. However, the presence of visual defects in blister packages can adversely affect the drug's bioavailability and therapeutic efficacy,...

DOAJ Open Access (DOAJ) DOI: 10.1007/s44196-025-00986-2