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Phosphopeptide binding to the N-SH2 domain of tyrosine phosphatase SHP2 correlates with the unzipping of its central β-sheet

Michelangelo Marasco, John Kirkpatrick, Teresa Carlomagno, Jochen S. Hub et al. • Computational and Structural Biotechnology Journal (2024)

SHP2 is a tyrosine phosphatase that plays a regulatory role in multiple intracellular signaling cascades and is known to be oncogenic in certain contexts. In the absence of effectors, SHP2 adopts an autoinhibited conformation with its N-SH2...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.csbj.2024.02.023

Fitness-based models and pairwise comparison models of evolutionary games are typically different—even in unstructured populations

Bin Wu, Benedikt Bauer, Tobias Galla, Arne Traulsen • New Journal of Physics (2015)

The modeling of evolutionary game dynamics in finite populations requires microscopic processes that determine how strategies spread. The exact details of these processes are often chosen without much further consideration. Different types ...

DOAJ Open Access (DOAJ) DOI: 10.1088/1367-2630/17/2/023043

Implications of climate change on freshwater ecosystems and their biodiversity

Divya Nimma, Okram Ricky Devi, Bibek Laishram, Janjhyam Venkata Naga Ramesh et al. • Desalination and Water Treatment (2025)

Global warming is a phenomenon whereby the planet's exposure to the sun's radiation worsens from the high emission of gasses believed to trap heat within the atmosphere. Carbon dioxide (CO2) is the leading greenhouse gas majorly responsible...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.dwt.2024.100889

The works of А. N. Radishchev: A study of economic and anthropological interpretation

Vadim A. Maximov • Известия Саратовского университета. Новая серия: Серия «Экономика. Управление. Право» (2022)

Introduction. A. N. Radishchev in his writings lays the foundations of a humanistic study of Russian society and an anthropological understanding of economic orders. Most of the works were not published during his lifetime; the scientific ...

DOAJ Open Access (DOAJ) DOI: 10.18500/1994-2540-2022-22-4-384-395

Evolution of traditional Chinese medicine registration review and approval policies: research based on the LDA topic model

Kaidi Lu, Ming Xie, Wanping Sun, Yiming Liu • Frontiers in Public Health (2025)

IntroductionThe economic expansion of the Traditional Chinese Medicine (TCM) industry has prompted the Chinese government to introduce a series of policies focused on the registration review and approval of TCM. These policies aim to provid...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpubh.2025.1655636

Sleep behaviours and associated habits and the progression of pre-diabetes to type 2 diabetes mellitus in adults: A systematic review and meta-analysis

Samiul A Mostafa, Sandra Campos Mena, Christina Antza, George Balanos et al. • Diabetes & Vascular Disease Research (2022)

Introduction Certain sleep behaviours increase risk of type 2 diabetes mellitus (T2DM) in the general population, but whether they contribute to the progression from pre-diabetes to T2DM is uncertain. We conducted a systematic review to ass...

DOAJ Open Access (DOAJ) DOI: 10.1177/14791641221088824

Applicability of tools to identify potentially inappropriate prescribing in elderly during medication review: Comparison of STOPP/START version 2, Beers 2019, EU(7)-PIM list, PRISCUS list, and Amsterdam tool—A pilot study

Agnieszka Lisowska, Edyta Czepielewska, Martyna Rydz, Anna Dworakowska et al. • PLoS ONE (2022)

Potentially inappropriate prescribing (PIP) is one of the major risk factors of adverse drug events in elderly patients. Pharmacotherapy assessment criteria may help reduce the instances of PIP among geriatric patients. This study aimed to ...

DOAJ Open Access (DOAJ)

Dla kogo i o czym? Muzeum Polin, historiografia Żydów a Żydzi jako „sprawa polska" [For whom and about what? The Polin Museum, Jewish historiography and Jews as a “Polish cause”]

Kamil Kijek • Studia Litteraria et Historica (2017)

For whom and about what? The Polin Museum, Jewish historiography and Jews as a “Polish cause” The article presents main threads of the ongoing debate around the permanent exhibition of the Polin Museum of the History of Polish Jews in Wars...

DOAJ Open Access (DOAJ) DOI: 10.11649/slh.1363

Immunological and Viral Profiles of Squamous Cell Carcinoma in Transplant and Non‐Transplant Patients in Singapore

Choon Chiat Oh, Boon Yee Lim, Elizabeth Chun Yong Lee, Bavani Kannan et al. • JEADV Clinical Practice (2025)

ABSTRACT Background Cutaneous squamous cell carcinoma (cSCC) remains poorly understood at the molecular level, both in the immunocompetent and immunosuppressed population with skin of colour. Data on the diversity of viruses found in cSCC i...

DOAJ Open Access (DOAJ) DOI: 10.1002/jvc2.70142

Features of reproduction of the shrub vole <i>Microtus majori</i> Thomas, 1906 in natural conditions

R. I. Dzuev, A. A. Cheprakova, F. H. Zhilyaeva, K. A. Mashukova • Юг России: экология, развитие (2020)

Aim. The purpose of this research based on the study of the ecological and biological characteristics of the shrub vole is to expand knowledge about patterns of microevolution in space, ecology and biology on the basis of which to assess th...

DOAJ Open Access (DOAJ) DOI: 10.18470/1992-098-2020-2-150-157

Antidiarrheal and antimicrobial profiles extracts of the leaves from Trichilia emetica Vahl. (Meliaceae)

Kiessoun Konaté, Kassi Yomalan, Oksana Sytar, Marian Brestic • Asian Pacific Journal of Tropical Biomedicine (2015)

Objective: To evaluate anti-diarrhoeal and antimicrobial activities of the bioactive fraction of Trichilia emetica in order to provide a scientific basis for the management of gastroenteritis in Burkina Faso. Methods: To do this, polyphenol...

DOAJ Open Access (DOAJ) DOI: 10.1016/S2221-1691(15)30012-5

Formulation optimization and flavor quality assessment of ginger tea

Shouhui Wei, Qiao Tan, Weining Wei, Hongbo Jiang et al. • Journal of Agriculture and Food Research (2026)

Ginger (Zingiber officinale Roscoe) is a characteristic economic crop with both medicinal and edible functions. The aroma and bioactive compounds in ginger tea are primarily derived from ginger. Developing a novel ginger tea with a rich aro...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jafr.2026.102977

CCR4, a RNA decay factor, is hijacked by a plant cytorhabdovirus phosphoprotein to facilitate virus replication

Zhen-Jia Zhang, Qiang Gao, Xiao-Dong Fang, Zhi-Hang Ding et al. • eLife (2020)

Carbon catabolite repression 4 (CCR4) is a conserved mRNA deadenylase regulating posttranscriptional gene expression. However, regulation of CCR4 in virus infections is less understood. Here, we characterized a pro-viral role of CCR4 in rep...

DOAJ Open Access (DOAJ) DOI: 10.7554/eLife.53753

Prospects for developing allergen‐depleted food crops

Vadthya Lokya, Sejal Parmar, Arun K. Pandey, Hari K. Sudini et al. • The Plant Genome (2023)

Abstract In addition to the challenge of meeting global demand for food production, there are increasing concerns about food safety and the need to protect consumer health from the negative effects of foodborne allergies. Certain bio‐molecu...

DOAJ Open Access (DOAJ) DOI: 10.1002/tpg2.20375

Shared but Threatened: The Heritage of Wild Food Plant Gathering among Different Linguistic and Religious Groups in the Ishkoman and Yasin Valleys, North Pakistan

Muhammad Abdul Aziz, Arshad Mehmood Abbasi, Zahid Ullah, Andrea Pieroni • Foods (2020)

A wild food ethnobotanical field study was conducted in the Ishkoman and Yasin valleys, located in the Hindukush Mountain Range of Gilgit-Baltistan, northern Pakistan. These valleys are inhabited by diverse, often marginalized, linguistic a...

DOAJ Open Access (DOAJ) DOI: 10.3390/foods9050601