Academic Articles & Research Papers

Research advances in Apert syndrome

Apert syndrome is one of the several genetic syndromes associated with craniosynostosis, a condition that includes premature fusion of one or multiple cranial sutures. There has been significant clinical variation among different sutural sy...

Assessment of Insert Sizes and Adapter Content in Fastq Data from NexteraXT Libraries

The Illumina NexteraXT transposon protocol is a cost effective way to generate paired end libraries. However the resulting insert size is highly sensitive to the concentration of DNA used, and the variation of insert sizes is often large. O...

A Comparative Analysis of the Chloroplast Genomes of Four Polygonum Medicinal Plants

Polygonum is a generalized genus of the Polygonaceae family that includes various herbaceous plants. In order to provide aid in understanding the evolutionary and phylogenetic relationship in Polygonum at the chloroplast (cp) genome-scale l...

Causal relationship between genetic-predicted uric acid and cervical cancer risk: evidence for nutritional intervention on cervical cancer prevention

IntroductionThe relationship between serum uric acid (SUA) and cervical cancer is inconclusive. This study aims to investigate the causal relationship between SUA levels and cervical cancer incidence, and to evaluate the potential role of n...

HumanViCe: Host ceRNA network in virus infected cells in human

Host-virus interaction via host cellular components has been an important field of research in recent times. RNA interference mediated by short interfering RNAs and microRNAs (miRNA), is a widespread anti-viral defence strategy. Importantly...

Effectiveness of Ultrasound Imaging in Assessing the Palpation Skills of Rotating Physicians

As an important means of physical examination, palpation is usually limited to the physical examination before surgery and used as an auxiliary method for disease diagnosis in the field of surgery. In practice, palpation is also used in eve...

Epigenetic alterations in mesenchymal stem cells by osteosarcoma-derived extracellular vesicles

Extracellular vesicles (EVs) are central to intercellular communication and play an important role in cancer progression and development. Osteosarcoma (OS) is an aggressive bone tumour, characterized by the presence of malignant mesenchymal...

P521: Withdrawn

CRISPR/Cas9 for hepatitis B virus infection treatment

Abstract Hepatitis B virus (HBV) infection remains a global health challenge. Despite the availability of effective preventive vaccines, millions of people are at risk of cirrhosis and hepatocellular carcinoma. Current drug therapies inhibi...

Monogenic obesity due to MC4R deficiency: lessons from a multigenerational case

Abstract Background Melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity, yet remains underdiagnosed. Patients with monogenic obesity often undergo a frustrating diagnostic and therapeutic odyssey of years...

Abnormal X : autosome ratio, but normal X chromosome inactivation in human triploid cultures

Abstract Background X chromosome inactivation (XCI) is that aspect of mammalian dosage compensation that brings about equivalence of X-linked gene expression between females and males by inactivating one of the two X chromosomes (Xi) in nor...

Genetics and Education

Genetics and education

Behavioral genetics, a primer

"Behavioural Genetics", fourth edition provides an overview of human and animal behavioural genetics that is designed to introduce students in the behavioural, biological, and social sciences to the field. With the addition of new chapters,...

Human Genetics

Introduction to Conservation Genetics

This impressive author team brings the wealth of advances in conservation genetics into the new edition of this introductory text, including new chapters on population genomics and genetic issues in introduced and invasive species. They con...

A history of genetics

Note from the Publishers Introduction Author's Preface Chapter 1: Before Mendel Chapter 2: Mendel Chapter 3: 1866 to 1900 Chapter 4: The Rediscovery Chapter 5: Genes and Chromosomes Chapter 6: Linkage Chapter 7: The Fly Room Chapter 8: Deve...

Genetics, Paleontology, and Evolution

Genetics of MDS

Our knowledge about the genetics of myelodysplastic syndromes (MDS) and related myeloid disorders has been dramatically improved during the past decade, in which revolutionized sequencing technologies have played a major role. Through inten...

Genetics of Obesity

Genetics of Human Obesities: Introductory Notes (C. Bouchard). Etiology and Prevalence of Obesity (G.A. Bray). Nongenetic Determinants of Obesity and Body Fat Topography (J.O. Hill, M.J. Pagliassotti, and J.C. Peters). Overview of the Adopt...