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Injectable mesoporous bioactive glass/sodium alginate hydrogel loaded with melatonin for intervertebral disc regeneration

Ruibang Wu, Leizhen Huang, Qinghong Xia, Zheng Liu et al. • Materials Today Bio (2023)

Intervertebral disc degeneration (IDD) is a major contributing factor to both lower back and neck pain. As IDD progresses, the intervertebral disc (IVD) loses its ability to maintain its disc height when subjected to axial loading. This fai...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.mtbio.2023.100731

THERAPEUTIC EFFECT OF PACLITAXEL LOADED ON GOLD NANOPARTICLES IN TREATMENT OF INDUCED ORAL SQUAMOUS CELL CARCINOMA

Fatma H. El-Didi, Marwa M. Essawy, Sagy L. Asar, Sahar M. El-Sheikh et al. • Alexandria Dental Journal (2019)

INTRODUCTION: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide with high mortality rate. Conventional treatment strategies have improved but remain far from optimal. Cancer research is focused on improving cance...

DOAJ Open Access (DOAJ) DOI: 10.21608/adjalexu.2019.57569

Identification and Validation of PLOD2 as an Adverse Prognostic Biomarker for Oral Squamous Cell Carcinoma

Yawei Sun, Shuai Wang, Xingwei Zhang, Zhuhao Wu et al. • Biomolecules (2021)

Background: Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), a key enzyme that catalyzes the hydroxylation of lysine, plays a crucial role in the progression of several solid tumors. However, its spatial expression profile and pr...

DOAJ Open Access (DOAJ) DOI: 10.3390/biom11121842

Unveiling Insights into the Whole Genome Sequencing of <i>Mycobacterium</i> spp. Isolated from Siamese Fighting Fish (<i>Betta splendens</i>)

Nguyen Dinh-Hung, Samuel Mwakisha Mwamburi, Ha Thanh Dong, Channarong Rodkhum et al. • Animals (2024)

This study aims to genomically elucidate six isolates of rapidly growing non-tuberculous mycobacteria (RGM) derived from Siamese fighting fish (Betta splendens). These isolates had previously undergone phenotypic and biochemical characteriz...

DOAJ Open Access (DOAJ) DOI: 10.3390/ani14192833

Transcriptomes Suggest That Pinniped and Cetacean Brains Have a High Capacity for Aerobic Metabolism While Reducing Energy-Intensive Processes Such as Synaptic Transmission

Cornelia Geßner, Alena Krüger, Lars P. Folkow, Wilfrid Fehrle et al. • Frontiers in Molecular Neuroscience (2022)

The mammalian brain is characterized by high energy expenditure and small energy reserves, making it dependent on continuous vascular oxygen and nutritional supply. The brain is therefore extremely vulnerable to hypoxia. While neurons of mo...

DOAJ Open Access (DOAJ) DOI: 10.3389/fnmol.2022.877349

Multiple organ failure in the newborn: the point of view of the pathologist

Clara Gerosa, Eleonora Obinu, Daniela Fanni, Rossano Ambu et al. • Journal of Pediatric and Neonatal Individualized Medicine (2014)

One of the most severe events occurring in critically ill patients admitted to a neonatal intensive care unit (NICU) center is represented by the multiple organ failure (MOF), a systemic inflammatory response leading to a progressive organ ...

DOAJ Open Access (DOAJ) DOI: 10.7363/030265

Identification of DDIT4 as a potential prognostic marker associated with chemotherapeutic and immunotherapeutic response in triple-negative breast cancer

Xuanzhao Chen, Zeyan Li, Meihua Liang, Ziyang Zhang et al. • World Journal of Surgical Oncology (2023)

Abstract Background Triple-negative breast cancer (TNBC) is the most heterogenous and aggressive subtype of breast cancer. Chemotherapy remains the standard treatment option for patients with TNBC owing to the unavailability of acceptable t...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12957-023-03078-7

Anti-ceramide antibody and sphingosine-1-phosphate as potential biomarkers of unresectable non-small cell lung cancer

Lilla Bűdi, Dániel Hammer, Rita Varga, Veronika Müller et al. • Pathology and Oncology Research (2025)

ObjectivesSpingosine-1-phosphate (S1P) and ceramides are bioactive sphingolipids that influence cancer cell fate. Anti-ceramide antibodies might inhibit the effects of ceramide. The aim of this study was to assess the potential role of circ...

DOAJ Open Access (DOAJ) DOI: 10.3389/pore.2024.1611929

Preoperative Radiological Findings Prior Endoscopic Dacryocystorhinostomy in Patients with Nasolacrimal Duct Obstruction

Heba Mahmoud Hamdy, Ahmed Abdelrahman • Zagazig University Medical Journal (2025)

Background: Epiphora is a common condition brought on by blockage of the nasolacrimal duct. In order to diagnose and treat these patients, it is critical to evaluate their lacrimal drainage system. This study aimed to identify and analyze t...

DOAJ Open Access (DOAJ) DOI: 10.21608/zumj.2025.395057.4007

Impact of the Age of Cecal Material Transfer Donors on Alzheimer’s Disease Pathology in 5xFAD Mice

Francesco Valeri, Malena dos Santos Guilherme, Fuqian He, Nicolai M. Stoye et al. • Microorganisms (2021)

Alzheimer’s disease is a progressive neurodegenerative disorder affecting around 30 million patients worldwide. The predominant sporadic variant remains enigmatic as the underlying cause has still not been identified. Since efficient therap...

DOAJ Open Access (DOAJ) DOI: 10.3390/microorganisms9122548

Association of SLC6A3 variants with treatment-resistant schizophrenia: a genetic association study of dopamine-related genes in schizophrenia

Masanobu Kogure, Nobuhisa Kanahara, Atsuhiro Miyazawa, Atsuhiro Miyazawa et al. • Frontiers in Psychiatry (2024)

BackgroundMost genetic analyses that have attempted to identify a locus or loci that can distinguish patients with treatment-resistant schizophrenia (TRS) from those who respond to treatment (non-TRS) have failed. However, evidence from mul...

DOAJ Open Access (DOAJ) DOI: 10.3389/fpsyt.2023.1334335

Genetic impact of non-consanguineous marriages in Saudi Arabia.

Mohammed Alyahya, Taghrid Aloraini, Youseef Al-Harbi, Lamia Alsubaie et al. • Journal of Biochemical and Clinical Genetics (2022)

Background: Physicians and geneticists face challenges in making accurate diagnoses during clinical evaluations; affecting patients and clinicians. The aim of this study was to estimate the hit rate of the non-consanguineous population. Mor...

DOAJ Open Access (DOAJ) DOI: 10.24911/JBCGenetics/183-1664872492

Fungal Communities Associated with Siricid Wood Wasps: Focus on <i>Sirex juvencus</i>, <i>Urocerus gigas</i>, and <i>Tremex fuscicornis</i>

Adas Marčiulynas, Jūratė Lynikienė, Artūras Gedminas, Aistė Povilaitienė et al. • Insects (2024)

We investigated the diversity and occurrence of wood wasps in Lithuania and determined communities of associated fungi. Trapping of wood wasps resulted in three different species, including Sirex juvencus, Urocerus gigas, and Tremex fuscico...

DOAJ Open Access (DOAJ) DOI: 10.3390/insects15010049

miR-3113-5p, miR-223-3p, miR-133a-3p, and miR-499a-5p are sensitive biomarkers to diagnose sudden cardiac death

Fengping Yan, Yuanyuan Chen, Xing Ye, Fu Zhang et al. • Diagnostic Pathology (2021)

Abstract Background Sudden cardiac death (SCD) remains a great health threat and diagnostic challenge, especially those cases without positive autopsy findings. Molecular biomarkers have been urgently needed for the diagnosis of SCD display...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13000-021-01127-x

Lipofuscin: Wear Pigment or Alarm Signal for Cardiac AlloGraft Vasculopathy?

Anca Otilia Farcas, Mihai Ciprian Stoica, Septimiu Voidazan, Carmen Corina Radu et al. • Diagnostics (2026)

Background: CAV (cardiac allograft vasculopathy) is considered the leading cause of late post-transplant mortality and affects approximately 50% of transplant patients at 10 years post-transplant. Its etiopathogenetic mechanism is considere...

DOAJ Open Access (DOAJ) DOI: 10.3390/diagnostics16152432

Does wet-cupping therapy improve repeated sprint ability, perceived wellness, and rating of perceived exertion in young active males?

Ismail Dergaa, Amine Ghram, Mohamed Romdhani, Amine Souissi et al. • Sports Medicine and Health Science (2024)

Wet-cupping therapy (WCT) is one of the oldest known medical techniques, used as a traditional and complementary therapy with a wide application all around the world for general health. Research on the effects of WCT on sports performance a...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.smhs.2023.09.007

Cadmium sulfide-induced toxicity in the cortex and cerebellum: In vitro and in vivo studies

Atefeh Varmazyari, Ali Taghizadehghalehjoughi, Cigdem Sevim, Ozlem Baris et al. • Toxicology Reports (2020)

Living organisms have an innate ability to regulate the synthesis of inorganic materials, such as bones and teeth in humans. Cadmium sulfide (CdS) can be utilized as a quantum dot that functions as a unique light-emitting semiconductor nano...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.toxrep.2020.04.011

Impact of <i>Chlorella vulgaris</i> Bioremediation and Selenium on Genotoxicity, Nephrotoxicity and Oxidative/Antioxidant Imbalance Induced by Polystyrene Nanoplastics in African Catfish (<i>Clarias gariepinus</i>)

Shimaa A. Abdelbaky, Zakaria M. Zaky, Doha Yahia, Mohamed H. Kotob et al. • Fishes (2024)

Contamination of the environment with nano- and microplastic particles exerts a threatening impact on the aquatic ecosystems and sustainable catfish aquaculture. The presence of nanoplastics has been found to have a detrimental impact on bo...

DOAJ Open Access (DOAJ) DOI: 10.3390/fishes9020076

RESTRICION FRAGMENT LENGTH POLYMORPHISM ANALYSIS OF JORDANIAN FIELD STRAINS OF INFECTIOUS BURSAL DISEASE VIRUS

M.Q. AL-NATOUR • Assiut Veterinary Medical Journal (2006)

Reverse transcriptase-polymerase chain reaction/ restriction fragment length polymorphism (RT-PCR/RFLP) techniques were used for the preliminary characterization of Jordanian field strains of Infectious Bursal Disease Viruses (IBDVs). Bursa...

DOAJ Open Access (DOAJ) DOI: 10.21608/avmj.2006.177318

Dietary Supplementation with the Red Seaweed <i>Porphyra umbilicalis</i> Protects against DNA Damage and Pre-Malignant Dysplastic Skin Lesions in HPV-Transgenic Mice

Susana Santos, Tiago Ferreira, José Almeida, Maria J. Pires et al. • Marine Drugs (2019)

Some diet profiles are associated with the risk of developing cancer; however, some nutrients show protective effects. Porphyra umbilicalis is widely consumed, having a balanced nutritional profile; however, its potential for cancer chemopr...

DOAJ Open Access (DOAJ) DOI: 10.3390/md17110615