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Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Yan Dora Zhang, Amber N. Hurson, Haoyu Zhang, Parichoy Pal Choudhury et al. • Nature Communications (2020)

In cancer many gene variants may contribute to disease etiology, but the impact of a given gene variant may have varied effect size. Here, the authors analyse summary statistics of genome-wide association studies from fourteen cancers, and ...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-020-16483-3

Unraveling the Secrets of a Double-Life Fungus by Genomics: <i>Ophiocordyceps australis</i> CCMB661 Displays Molecular Machinery for Both Parasitic and Endophytic Lifestyles

Thaís Almeida de Menezes, Flávia Figueira Aburjaile, Gabriel Quintanilha-Peixoto, Luiz Marcelo Ribeiro Tomé et al. • Journal of Fungi (2023)

Ophiocordyceps australis (Ascomycota, Hypocreales, Ophiocordycipitaceae) is a classic entomopathogenic fungus that parasitizes ants (Hymenoptera, Ponerinae, Ponerini). Nonetheless, according to our results, this fungal species also exhibits...

DOAJ Open Access (DOAJ) DOI: 10.3390/jof9010110

Mikania micrantha genome provides insights into the molecular mechanism of rapid growth

Bo Liu, Jian Yan, Weihua Li, Lijuan Yin et al. • Nature Communications (2020)

Mikania micrantha is an extremely fast-growing invasive plant species that can cause serious damage to natural ecosystems. Here, the authors assemble its chromosome-scale reference genome and explore possible mechanisms that contribute to i...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-019-13926-4

Floristic diversity and structural parameters on the forest tree population in the Luki biosphere reserve, Democratic Republic of Congo

Sylvain Ambayi Bienu, Tolerant K. Lubalega, Damase P. Khasa, David Kombi kaviriri et al. • Global Ecology and Conservation (2023)

Tropical rainforests play an important role in the global Eco-climatic balance and its sustainable management is a major concern that has attracted the attention of researchers. The Luki biosphere reserve, while under a status of protected ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.gecco.2023.e02489

Masterbatch-enabled acceleration of polyolefin biodegradation under open air terrestrial environmental conditions

Ceren Kütahya, Catalina Cruañas Pániker, Faith Ly, Arjun Jerath et al. • npj Materials Degradation (2026)

Abstract Polyolefins, commonly used in packaging and single-use products, are notoriously persistent in the environment, contributing significantly to environmental pollution. In scientific literature to date, polyolefins have not been repo...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41529-026-00817-5

Effect of physiochemical parameters on yield and biological efficiency of Volvariella volvacea cultivated on empty fruit bunch pellets

Nur Fariha Amir, Aslizah Mohd-Aris, Tuan Norhafizah Tuan-Zakaria, Noor Azrimi Umor et al. • Heliyon (2025)

Background: Volvariella volvacea is a highly nutritious edible mushroom grown mainly in Southeast Asian countries. However, the low yield of V. volvacea has discouraged farmers from engaging in its production. Objective: The study was condu...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2025.e42572

SARS-CoV-2 Omicron BA.2.75 Variant May Be Much More Infective than Preexisting Variants Based on In Silico Model

Aki Sugano, Yutaka Takaoka, Haruyuki Kataguchi, Mika Ohta et al. • Microorganisms (2022)

Previously, we developed a mathematical model via molecular simulation analysis to predict the infectivity of six SARS-CoV-2 variants. In this report, we aimed to predict the relative risk of the recent new variants of SARS-CoV-2 based on o...

DOAJ Open Access (DOAJ) DOI: 10.3390/microorganisms10102090

Multi-omics for studying and understanding polar life

M. S. Clark, J. I. Hoffman, L. S. Peck, L. Bargelloni et al. • Nature Communications (2023)

Abstract Polar ecosystems are experiencing amongst the most rapid rates of regional warming on Earth. Here, we discuss ‘omics’ approaches to investigate polar biodiversity, including the current state of the art, future perspectives and rec...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-023-43209-y

Improved chromosomal-level genome assembly and re-annotation of leopard coral grouper

Wentao Han, Shaoxuan Wu, Hui Ding, Mingyi Wang et al. • Scientific Data (2023)

Abstract Plectropomus leopardus, as known as leopard coral grouper, is a valuable marine fish that has gradually been bred artificially. To promote future conservation, molecular breeding, and comparative studies, we generated an improved h...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41597-023-02051-z

Bioconversion of Date Waste into Bacterial Nanocellulose by a New Isolate <i>Komagataeibacter</i> sp. IS22 and Its Use as Carrier Support for Probiotics Delivery

Islam Sayah, Ibtissem Chakroun, Claudio Gervasi, Davide Barreca et al. • Foods (2025)

Bacterial nanocellulose (BNC) has gained considerable interest over the last decade due to its unique properties and versatile applications. However, the low yield and the high production cost significantly limit its industrial scalability....

DOAJ Open Access (DOAJ) DOI: 10.3390/foods14162853

Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits

Mateus H. Gouveia, Amy R. Bentley, Hampton Leonard, Karlijn A. C. Meeks et al. • Scientific Reports (2021)

Abstract Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specif...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-021-83450-3

The recurrent WASF1 nonsense variant identified in two unaffected Chinese families with neurodevelopmental disorder: case report and review of the literatures

Xiang Tang, Guoqing Liu, Li Lin, Nong Xiao et al. • BMC Medical Genomics (2023)

Abstract Background Neurodevelopmental disorder with absent language and variable seizures (NEDALVS, # 618707) are characterized by delayed speech and motor development, ocular abnormalities, and seizures. NEDAVLS is an autosomal dominant d...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12920-023-01630-8

High-quality read-based phasing of cystic fibrosis cohort informs genetic understanding of disease modification

Scott Mastromatteo, Angela Chen, Jiafen Gong, Fan Lin et al. • HGG Advances (2023)

Summary: Phasing of heterozygous alleles is critical for interpretation of cis-effects of disease-relevant variation. We sequenced 477 individuals with cystic fibrosis (CF) using linked-read sequencing, which display an average phase block ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.xhgg.2022.100156

Chromosome-level genome assembly and population genomics analysis of Camellia rubituberculata provide insights into adaptation to karst habitats

Chao Yan, Ming-tai An, Ming Tang, Xin-xiang Bai et al. • Plant Diversity (2026)

Karst flora confined to isolated ‘habitat islands’ evolve specialized adaptations and unique traits, serving as ideal models for investigating adaptive evolution and species diversification mechanisms. Camellia rubituberculata, endemic to t...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.pld.2025.09.004

Genome-based development of 15 microsatellite markers in fluorescent multiplexes for parentage testing in captive tigers

Xiao Zhao, Qiguan Qiu, Chang Li, Dongke Fu et al. • PeerJ (2020)

As one of the most endangered species, tiger (Panthera tigris) inbreeding has become an urgent issue to address. Using a microsatellite (short tandem repeat, STR) identification system, paternity testing may be helpful to avoid inbreeding i...

DOAJ Open Access (DOAJ) DOI: 10.7717/peerj.8939

Effects of an infant formula containing a whey protein concentrate on feeding tolerance and markers of intestinal immune defense in Chinese infants

Ying Wang, Min Liu, Shaillay Kumar Dogra, Karine Vidal et al. • BMC Nutrition (2026)

Abstract Background Human milk (HM) bioactive components can have immune modulatory functions, impact the gut microbiome, and may result in functional benefits when added to infant formula (IF). In this single-arm, prospective, intervention...

DOAJ Open Access (DOAJ) DOI: 10.1186/s40795-026-01395-0

The Downregulation of eIF3a Contributes to Vemurafenib Resistance in Melanoma by Activating ERK via PPP2R1B

Shi-Long Jiang, Shi-Long Jiang, Zhi-Bin Wang, Zhi-Bin Wang et al. • Frontiers in Pharmacology (2021)

Vemurafenib, a BRAF V600E inhibitor, provides therapeutic benefits for patients with melanoma, but the frequent emergence of drug resistance remains a challenge. An understanding of the mechanisms underlying vemurafenib resistance may gener...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphar.2021.720619