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CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling

Xindong Wei, Anfeng Si, Shuai Zhao, Yi Fu et al. • Cellular & Molecular Biology Letters (2025)

Abstract Background Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (H...

DOAJ Open Access (DOAJ) DOI: 10.1186/s11658-025-00690-1

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury

Alessandro L. Gallina, Urszula Rykaczewska, Robert C. Wirka, Robert C. Wirka et al. • Frontiers in Cardiovascular Medicine (2021)

Objectives and Aims: Vascular smooth muscle cells (VSMCs) are key constituents of both normal arteries and atherosclerotic plaques. They have an ability to adapt to changes in the local environment by undergoing phenotypic modulation. An im...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcvm.2021.655869

Fyn Kinase: A Potential Target in Glucolipid Metabolism and Diabetes Mellitus

Ruifeng Xiao, Cong Shen, Wen Shen, Xunan Wu et al. • Current Issues in Molecular Biology (2025)

Fyn is widely involved in diverse cellular physiological processes, including cell growth and survival, and has been implicated in the regulation of energy metabolism and the pathogenesis of diabetes mellitus through multiple pathways. Fyn ...

DOAJ Open Access (DOAJ) DOI: 10.3390/cimb47080623

Confined migration induces heterochromatin formation and alters chromatin accessibility

Chieh-Ren Hsia, Jawuanna McAllister, Ovais Hasan, Julius Judd et al. • iScience (2022)

Summary: During migration, cells often squeeze through small constrictions, requiring extensive deformation. We hypothesized that nuclear deformation associated with such confined migration could alter chromatin organization and function. B...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.isci.2022.104978

Unrevealing the dual role of paired box and sex determining region Y related high mobility group box in glioblastoma

Kallol Polley, Sayed Mohammed Firdous • Discover Oncology (2026)

Abstract This narrative review summarises glioblastoma (GBM), a very frequent invasive kind of brain tumour in the elderly that is extremely aggressive, resistant to treatment, and has a bad prognosis because of its substantial genetic and ...

DOAJ Open Access (DOAJ) DOI: 10.1007/s12672-026-04671-4

P2′ Site Scanning of Snake Kunitz-Type Toxin Analogue BF9-N17H with Unique P1 Site Histidine Highlights Novel XIa Inhibitory Peptides Without Plasmin Inhibitory Activity

Luyao Wang, Li Ding, Tianxiang Qin, Xinyu Liu et al. • Toxins (2026)

Kunitz-type peptides from venomous and blood-sucking animals represent an important natural molecular resource for anticoagulant development towards XIa, a new target for antithrombotic drug discovery. However, the plasmin-inhibitory activi...

DOAJ Open Access (DOAJ) DOI: 10.3390/toxins18100449

Extracellular vesicles derived from mesenchymal stromal cells mitigate intestinal toxicity in a mouse model of acute radiation syndrome

Alison Accarie, Bruno l’Homme, Mohamed Amine Benadjaoud, Sai Kiang Lim et al. • Stem Cell Research & Therapy (2020)

Abstract Background Human exposure to high doses of radiation resulting in acute radiation syndrome and death can rapidly escalate to a mass casualty catastrophe in the event of nuclear accidents or terrorism. The primary reason is that the...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13287-020-01887-1

Unraveling genetic diversity in ‘Foşa’ and ‘Yomra’ hazelnut accessions (Corylus avellana L.) using SSR markers and phenotypic analysis

Yusuf Bilgen, Yaşar Akça, Kenan Yıldız, Kubilay Yıldırım • Scientific Reports (2026)

Abstract The Foşa hazelnut variety is commonly cultivated in Türkiye and is often confused with the Yomra variety due to morphological similarities. This study aims to determine the phenological and pomological characteristics of the Foşa a...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-026-44863-0

Toll-like receptor 2 coordinates induction of IL-22 in lung macrophages following organic dust-induced inflammation

Emmanuel O. Oyewole, Emmanuel O. Oyewole, Emmanuel O. Oyewole, Pinaki Mondal et al. • Frontiers in Physiology (2026)

IntroductionOrganic dust exposures, particularly in occupational settings, induce airway inflammation and contribute to the development and progression of chronic lung disease and impaired tissue regeneration. Interleukin-22 (IL-22) is a pl...

DOAJ Open Access (DOAJ) DOI: 10.3389/fphys.2026.1880821

The complete chloroplast genome of Dicliptera tinctoria (Nees) Kostel. and comparative analysis of chloroplast genomes in Acanthaceae

Thi Thanh Nga Le, Minh Thiet Vu, Hoang Dang Khoa Do • Genetics and Molecular Biology (2024)

Abstract Dicliptera tinctoria is a member of Acanthaceae, which has a wide distribution and contains potentially medicinal species, and exhibited pharmaceutical potentials. This study sequenced and characterized the complete chloroplast gen...

DOAJ Open Access (DOAJ) DOI: 10.1590/1678-4685-gmb-2023-0297

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome

Florian Köhler, Felix Bormann, Günter Raddatz, Julian Gutekunst et al. • Genome Medicine (2020)

Abstract Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected indiv...

DOAJ Open Access (DOAJ) DOI: 10.1186/s13073-020-00749-y

Innovative green niosomal piperlongumine as a novel topical treatment for dermatophytosis in guinea pigs model

Iman Haghani, Abbas Raeisabadi, Javad Akhtari, Aylar Arbabi et al. • Scientific Reports (2025)

Abstract Dermatophytosis is a common superficial fungal infection that affects many people worldwide. Although various species of dermatophytes respond to common antifungal drugs, the recently identified Trichophyton indotineae isolates hav...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-21729-5

Enhancing the oxidative cleavage of vicinal diols on Fe-ZSM-5 catalysts with hierarchical porosity

Philipp Treu, Dimitra Iltsiou, Rabia Elbuga-Ilica, Carina Maliakkal et al. • Sustainable Chemistry for the Environment (2025)

The oxidative cleavage of biomass-derived vicinal diols holds significant potential for producing valuable renewable carboxylic acids. Fe-ZSM-5 zeolite is a highly effective catalyst for this reaction using mild reaction conditions; however...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.scenv.2025.100232

Nanotechnology

JE Hulla, SC Sahu, Andrew Wallace Hayes • Human & Experimental Toxicology (2015)

Human dreams and imagination often give rise to new science and technology. Nanotechnology, a 21st-century frontier, was born out of such dreams. Nanotechnology is defined as the understanding and control of matter at dimensions between 1 a...

OPENALEX DOI: https://doi.org/10.1177/0960327115603588

Effect of heat treatment on the microstructure and corrosion resistance of laser powder bed fusion ODS-316L

Qian Zheng, Chao Lu, Yan Yin, Xiaoli Cui et al. • Journal of Materials Research and Technology (2025)

As a candidate cladding material for fourth-generation nuclear energy systems, the microstructure and properties of oxide dispersion strengthened 316L (ODS-316L) steel are significantly affected by heat treatment (HT) processes. This paper ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jmrt.2025.09.256

Performance debugging for distributed systems of black boxes

Marcos K. Aguilera, Jeffrey C. Mogul, Janet L. Wiener, Patrick Reynolds et al. • ACM SIGOPS Operating Systems Review (2003)

Many interesting large-scale systems are distributed systems of multiple communicating components. Such systems can be very hard to debug, especially when they exhibit poor performance. The problem becomes much harder when systems are compo...

OPENALEX DOI: https://doi.org/10.1145/1165389.945454

Optimal allocation and sizing of distributed generation for improvement of distribution feeder loss and voltage profile in the distribution network using genetic algorithm

Milkias Berhanu Tuka, Seid Endris Ali • Measurement + Control (2026)

The increasing demand for electric power, coupled with rapid urbanization, necessitates a reliable and high-quality electricity supply to meet consumer expectations. However, existing passive distribution systems are inadequate to address t...

DOAJ Open Access (DOAJ) DOI: 10.1177/00202940251323760