Academic Articles & Research Papers

Methodological framework to identify possible adverse drug reactions using population-based administrative data [v1; ref status: indexed, http://f1000r.es/3ys]

Purpose: We present a framework for detecting possible adverse drug reactions (ADRs) using the Utah Medicaid administrative data. We examined four classes of ADRs associated with treatment of dementia by acetylcholinesterase inhibitors (ACh...

SOCIAL MARKETING IN PUBLIC HEALTH

Social marketing, the use of marketing to design and implement programs to promote socially beneficial behavior change, has grown in popularity and usage within the public health community. Despite this growth, many public health profession...

Underweight, body image, and weight loss measures among adolescents in Saudi Arabia: is it a fad or is there more going on?

Background and Objective: Adolescence is considered to be a pivotal point in which optimum nutrition and eating habits are developed. Although tackling the obesity epidemic has been much discussed, addressing the issue of underweight and bo...

Genotypic Variants of Pandemic H1N1 Influenza A Viruses Isolated from Severe Acute Respiratory Infections in Ukraine during the 2015/16 Influenza Season

Human type A influenza viruses A(H1N1)pdm09 have caused seasonal epidemics of influenza since the 2009–2010 pandemic. A(H1N1)pdm09 viruses had a leading role in the severe epidemic season of 2015/16 in the Northern Hemisphere and caused a h...

Impact of preoperative insomnia on poor postoperative pain control after elective spine surgery and the modified Calgary postoperative pain after spine surgery (MCAPPS) score

Background: Approximately 30% to 64% of patients experience inadequate pain control following spine surgery. The Calgary postoperative pain after spine surgery (CAPPS) score was developed to identify this subset of patients. The impact of p...

The upregulated scavenger receptor CD36 is associated with the progression of nontarget lesions after stent implantation in atherosclerotic rabbits

Ruijian Li,1–3,* Sumei Cui,1–3,* Youshun Xu,4 Junhui Xing,5 Li Xue,1–3 Yuguo Chen1–3 1Department of Emergency, Qilu Hospital, Shandong University, Jinan, China; 2Key Laboratory of Emergency and Critical Care Medicine...

Awareness of COVID 19 pandemic among dental practioners of Telangana state, India: A cross sectional survey

Background: Coronavirus diseases (COVID-19) is a public health emergency of international concern. The dental professionals are considered to be at high risk, as most of the treatments may lead to the spread of infection due to direct proxi...

Prevalence and Determinants of Hypertension in Non-pregnant Women of Punjab

Background: Women’s hypertension (HTN) is often underestimated and goes untreated due to the perception that women have a lesser risk of cardiovascular disease compared to males. Objectives: The purpose of this study was to assess the preva...

Electrical and magnetic properties of antiferromagnetic semiconductor MnSi2N4 monolayer

Two-dimensional antiferromagnetic semiconductors have triggered significant attention due to their unique physical properties and broad application. Based on first-principles calculations, a novel two-dimensional (2D) antiferromagnetic mate...

Enhanced Reversibility of Li‐Rich Binary Oxide Cathodes through Synergistic Interfacial Regulation for Improved Charge Transfer Kinetics at High Depth of Charge/Discharge

Lithium‐rich manganese‐based oxides are accepted as a promising cathode material for high‐energy density batteries. However, they suffer from irreversible structural transformations and detrimental interfacial reactions, especially under de...

LASIK Surgery

Photo by Scott Van Daalen on Unsplash INTRODUCTION LASIK surgery, one of the most common elective procedures worldwide, aims to decrease or eliminate the need to wear glasses or contact lenses by reshaping the cornea’s curvature to re...

Protective effects of ceria nanoclusters against delayed paraplegia after spinal cord ischemia

Abstract Spinal cord ischemia reperfusion injury (SCIRI) induced delayed paraplegia is a complex complication of thoracoabdominal aortic surgery. Reactive oxygen species (ROS) play a critical role in the pathogenesis of delayed paraplegia, ...

Recent advances in surface functionalization of cardiovascular stents

Cardiovascular diseases (CVD) are the leading global threat to human health. The clinical application of vascular stents improved the survival rates and quality of life for patients with cardiovascular diseases. However, despite the benefit...

From Isolation to Application: Utilising Phage‐Antibiotic Synergy in Murine Bacteremia Model to Combat Multidrug‐Resistant Enterococcus faecalis

ABSTRACT Enterococcus species, natural inhabitants of the human gut, have become major causes of life‐threatening bloodstream infections (BSIs) and the third most frequent cause of hospital‐acquired bacteremia. The rise of high‐level gentam...

Case Report: Tocilizumab in pediatric febrile infection-related epilepsy syndrome

Background and purposeWe describe the clinical characteristics and the therapeutic effect of tocilizumab with Febrile Infection-Related Epilepsy Syndrome (FIRES). FIRES is characterized by super refractory status epilepticus (SRSE) in previ...

Hydrogen gas (H2) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction–associated steatotic liver disease in mice via inhibiting GSDMD- and GSDME-mediated pyroptosis

BackgroundHydrogen gas (H2), which is the lightest and diffusible gas molecule, has strong abilities to alleviate excessive oxidative stress, inflammation, and apoptosis. Inhalation of H2 is beneficial for preventing the damage of the lung,...

Advances in CAR T cell therapy: antigen selection, modifications, and current trials for solid tumors

Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies, achieving remarkable clinical success with FDA-approved therapies targeting CD19 and BCMA. However, the extension of these successe...

Wild immunology

In wild populations, individuals are regularly exposed to a wide range of pathogens. In this context, organisms must elicit and regulate effective immune responses to protect their health while avoiding immunopathology. However, most of our...

EP300 inhibition alleviates acute-on-chronic liver failure through modulation of scar-associated macrophages.

DNA methylation patterns of circadian and ultradian genes are altered in the peripheral blood of patients with hidradenitis suppurativa

BackgroundHidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects hair follicles in areas with apocrine sweat glands, such as the underarms, groin, and buttocks. The pathogenesis of HS is not fully understood, bu...