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Showing 20 of 1,492 academic articles

Lung cancer tumor immune microenvironment: analyzing immune escape mechanisms and exploring emerging therapeutic targets

Zhen Wang, Honglei Guo, Yanqi Song, Aidi Wang et al. • Frontiers in Immunology (2025)

Lung cancer is the most common malignant tumor in the world. Presently, there are still problems, including a high recurrence rate, resistance, and serious toxic side effects, even if conventional treatments like chemotherapy, radiotherapy,...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2025.1597686

Exposure of Microglia to Interleukin-4 Represses NF-κB-Dependent Transcription of Toll-Like Receptor-Induced Cytokines

Ella A. Zuiderwijk-Sick, Céline van der Putten, Raissa Timmerman, Jennifer Veth et al. • Frontiers in Immunology (2021)

Interleukin (IL)-4 is a cytokine that affects both adaptive and innate immune responses. In the central nervous system, microglia express IL-4 receptors and it has been described that IL-4-exposed microglia acquire anti-inflammatory propert...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2021.771453

Global variations in funding and use of hemodialysis accesses: an international report using the ISN Global Kidney Health Atlas

Anukul Ghimire, Samveg Shah, Utkarsh Chauhan, Kwaifa Salihu Ibrahim et al. • BMC Nephrology (2024)

Abstract Background There is a lack of contemporary data describing global variations in vascular access for hemodialysis (HD). We used the third iteration of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) to ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12882-024-03593-z

Biological Potential of <i>Tsuga canadensis</i>: A Study on Seed, Cone Essential Oils, and Seed Lipophilic Extract

Anna Wajs-Bonikowska, Ewa Maciejczyk, Łukasz Szoka, Paweł Kwiatkowski et al. • Applied Sciences (2025)

This study investigates the essential oil (EO) isolated from the seeds and cones of Canadian hemlock (Tsuga canadensis), highlighting notable differences in their chemical composition and biological activities. The seed EO was uniquely domi...

DOAJ Open Access (DOAJ) DOI: 10.3390/app15041713

The critical involvement of monocytes/macrophages in the pathogenesis of primary Sjögren's syndrome: New evidence from Mendelian randomization and single-cell sequencing

Yimei Ding, Xue Luan, Jiaqi Hou • Heliyon (2024)

Background: Primary Sjögren's syndrome (pSS) stands as a chronic autoimmune disease characterized by an elusive pathogenesis. The synergy of single-cell RNA sequencing and Mendelian randomization (MR) analysis provides an opportunity to com...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2024.e39130

Case Report: A severe case of immunosuppressant-refractory immune checkpoint inhibitor-mediated colitis rescued by tofacitinib

Mark W. D. Sweep, Mark W. D. Sweep, Martijn J. H. Tjan, Mark A. J. Gorris et al. • Frontiers in Immunology (2023)

Immune checkpoint inhibitor therapy for cancer treatment can give rise to a variety of adverse events. Here we report a male patient with metastatic melanoma who experienced life-threatening colitis and duodenitis following treatment with i...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2023.1212432

Shotgun metagenomic sequencing of serum extracellular vesicle-derived DNA enables microbial profiling in urothelial carcinoma

Toshihiro Uemura, Atsunari Kawashima, Kentaro Jingushi, Daisuke Motooka et al. • Scientific Reports (2026)

Abstract Shotgun metagenomic sequencing provides more detailed microbial information than 16 S rRNA sequencing but requires higher cost and larger sample volumes. We evaluated whether shotgun metagenomic sequencing could detect bacterial DN...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-026-59896-8

Free Amino Acids in Human Milk: A Potential Role for Glutamine and Glutamate in the Protection Against Neonatal Allergies and Infections

Joris H. J. van Sadelhoff, Selma P. Wiertsema, Johan Garssen, Johan Garssen et al. • Frontiers in Immunology (2020)

Breastfeeding is indicated to support neonatal immune development and to protect against neonatal infections and allergies. Human milk composition is widely studied in relation to these unique abilities, which has led to the identification ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fimmu.2020.01007

GROWTH AND YIELD RESPONSES OF SOYBEAN (Glycine max L.) TO ZINC OXIDE (ZnO) NANOPARTICLES FOLIAR APPLICATION

Fayomi Omotola Michael, Olasan Joseph Olalekan, Aguoru Celestine Uzoma, Terhemba Mamnenge Sarah • Biotechnologia Acta (2024)

Aim. This study was purposed to investigate the effects of zinc oxide nanoparticles (ZnO NPs) on the growth and yield performance of two soybean (Glycine max L.) varieties, TGX1904-6F and TGX1951-3F, under controlled experimental conditions...

DOAJ Open Access (DOAJ) DOI: 10.15407/biotech17.06.056

Electrospinning: A Powerful Tool to Improve the Corrosion Resistance of Metallic Surfaces Using Nanofibrous Coatings

Pedro J. Rivero, Deyo Maeztu Redin, Rafael J. Rodríguez • Metals (2020)

The use of surface engineering techniques to tune-up the composition of nanostructured thin-films for developing functional coatings with advanced properties is a hot topic within the scientific community. The control of the coating structu...

DOAJ Open Access (DOAJ) DOI: 10.3390/met10030350

Achieving high strength in 430 stainless steel by laser powder bed fusion: microstructure-property relationships and strengthening strategies

Junchen Li, Qiushuang Wang, Swee Leong Sing, Congwei Wang et al. • Virtual and Physical Prototyping (2026)

Conventional manufacturing of 430 ferritic stainless steel faces significant challenges, including severe work hardening, rapid tool wear, and limited strengthening via heat treatment. To overcome these limitations, this study employs laser...

DOAJ Open Access (DOAJ) DOI: 10.1080/17452759.2026.2631285

Bio-Template Synthesis of V<sub>2</sub>O<sub>3</sub>@Carbonized Dictyophora Composites for Advanced Aqueous Zinc-Ion Batteries

Wei Zhou, Guilin Zeng, Haotian Jin, Shaohua Jiang et al. • Molecules (2023)

In terms of new-generation energy-storing devices, aqueous zinc-ion batteries (AZIBs) are becoming the prime candidates because of their inexpensive nature, inherent safety, environmental benignity and abundant resources. Nevertheless, due ...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules28052147

Non-truncated strategy to exactly integrate the post-Newtonian Lagrangian circular restricted three-body problem

Li Huang, Lijie Mei, Shixiang Huang • European Physical Journal C: Particles and Fields (2018)

Abstract In this study, we present a novel non-truncated strategy by accompanying the fixed-point iteration with traditional numerical integrators. The proposed non-truncated strategy aims to exactly integrate implicit motion equations that...

DOAJ Open Access (DOAJ) DOI: 10.1140/epjc/s10052-018-6291-1

Change Detection for Hyperspectral Images Via Convolutional Sparse Analysis and Temporal Spectral Unmixing

Qingle Guo, Junping Zhang, Chongxiao Zhong, Ye Zhang • IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing (2021)

With the increase in the availability of multitemporal hyperspectral images (HSIs), HSIs change detection (CD) methods, including pixel-level and subpixel-level based methods, have attracted great attention in recent years. However, the wid...

DOAJ Open Access (DOAJ) DOI: 10.1109/JSTARS.2021.3074538

An Unsupervised and End-to-End Registration Method Using Offset Field and Pseudodata for Video SAR Images

Hui Fang, Guisheng Liao, Yongjun Liu, Cao Zeng et al. • IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing (2024)

Video synthetic aperture radar (video SAR) has been successfully applied in many fields and the registration of the video SAR images has been proven to be a crucial step in their preprocessing. However, video SAR images exhibit more severe ...

DOAJ Open Access (DOAJ) DOI: 10.1109/JSTARS.2024.3465835

Topical Pharmacological Treatment of Actinic Keratoses: Focus on Tirbanibulin 1% Ointment

Mario Valenti, Matteo Bianco, Alessandra Narcisi, Antonio Costanzo et al. • Dermatology Practical & Conceptual (2024)

Actinic keratosis (AK) is a frequent precancerous skin lesion that mostly affects chronically sun-exposed areas. Chronic sun damage leads to various mutations in onco-suppressor and oncogenic genes which cause an uncontrolled proliferation ...

DOAJ Open Access (DOAJ) DOI: 10.5826/dpc.1403S1a145S

Receptor allostery promotes context-specific Sonic Hedgehog signaling during embryonic development

Miriam E. Dillard, Christina A. Daly, Rojalin Pradhan, Shariq S. Ansari et al. • Nature Communications (2026)

Abstract Sonic Hedgehog (SHH) signaling functions in temporal- and context-dependent manners to pattern diverse tissues during embryogenesis. The signal transducer Smoothened (SMO) is induced by sterols, oxysterols, and arachidonic acid (AA...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-026-75918-5

Knockout of

Tushar K. Dutta, Voodikala S. Akhil, Utkarsh Chauhan, Prolay K. Bhowmick et al. • Rice Science (2026)

Direct-seeded rice (DSR) offers a sustainable alternative for climate-resilient agriculture, but it is severely threatened by the root-knot nematode Meloidogyne graminicola . Knockout of susceptibility (S) genes has emerged as a promising s...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.rsci.2026.05.008

Lipid-mediated gating of a miniature mechanosensitive MscS channel from Trypanosoma cruzi

Jingying Zhang, Aashish Bhatt, Grigory Maksaev, Yun Lyna Luo et al. • Nature Communications (2025)

Abstract The mechanosensitive channel of small conductance (MscS) from E. coli (EcMscS) has served as the prevailing model system for understanding mechanotransduction in ion channels. Trypanosoma cruzi, the protozoan parasite causing Chaga...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41467-025-62757-z