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ROS/Enzyme Dual-Responsive Drug Delivery System for Targeted Colorectal Cancer Therapy: Synergistic Chemotherapy, Anti-Inflammatory, and Gut Microbiota Modulation

Xin Zhang, Ruonan Lian, Bingbing Fan, Lei Meng et al. • Pharmaceutics (2025)

Objectives: Colorectal cancer (CRC) is a leading cause of cancer-related mortality, driven by chronic inflammation, gut microbiota dysbiosis, and complex tumor microenvironment interactions. Current therapies are limited by systemic toxicit...

DOAJ Open Access (DOAJ) DOI: 10.3390/pharmaceutics17070940

Discovery of sulfone-resistant dihydropteroate synthase (DHPS) as a target enzyme for kaempferol, a natural flavanoid

Angamba Meetei Potshangbam, Ravindranath Singh Rathore, Potshangbam Nongdam • Heliyon (2020)

Kaempferol is a ubiquitous flavonoid, found in various plants having a wide range of known pharmacological activities, including antioxidant, antiinflammatory, anticancer, antiallergic, antidiabetic, neuroprotective, cardioprotective and an...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2020.e03378

Guidelines for information about therapy experiments: a proposal on best practice for recording experimental data on cancer therapy

González-Beltrán Alejandra N, Yong May Y, Dancey Gairin, Begent Richard • BMC Research Notes (2012)

Abstract Background Biology, biomedicine and healthcare have become data-driven enterprises, where scientists and clinicians need to generate, access, validate, interpret and integrate different kinds of experimental and patient-related dat...

DOAJ Open Access (DOAJ) DOI: 10.1186/1756-0500-5-10

Generation Scotland: Linking all the records we can

Archie Campbell, Robin Flaig, Cathie Sudlow • International Journal of Population Data Science (2023)

Objectives We started a family-based genetic epidemiology study in 2006-11 which recruited ~24,000 adult volunteers from ~7000 families across Scotland with consent for follow-up through medical record linkage and re-contact. In 2022-23 we ...

DOAJ Open Access (DOAJ) DOI: 10.23889/ijpds.v8i2.2347

Women’s perception about the discovery of breast cancer amid the covid-19 pandemic

Simone Meira Carvalho, Camilla de Abrahão Andrade, Mariana Barbosa Leite Sérgio Ferreira, Karine Soriana Silva de Souza et al. • PLoS ONE (2023)

Background Breast cancer is considered a health problem at a worldwide level. In Brazil, the South and Southeast regions have the highest mortality rates. Understanding how they dealt with the diagnostic of a stigmatized disease amid the CO...

DOAJ Open Access (DOAJ)