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Assessment of the Nutritional and Medicinal Potential of Tubers from Hairy Stork’s-Bill (<i>Erodium crassifolium</i> L ’Hér), a Wild Plant Species Inhabiting Arid Southeast Mediterranean Regions

Shabtai Cohen, Hinanit Koltai, Gopinath Selvaraj, Moran Mazuz et al. • Plants (2020)

Emerging needs for diversifying human diet and to explore novel therapeutic procedures have led to increasing attempts to retrieve traditional nourishments and recruit beneficial wild plant species. Species of the genus Erodium (Geraniaceae...

DOAJ Open Access (DOAJ) DOI: 10.3390/plants9091069

The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate

Esteve Pilar, Lopez-Rios Javier, Ruiz Jose, Bovolenta Paola • Neural Development (2008)

Abstract Background Secreted frizzled related proteins (SFRPs) are multifunctional modulators of Wnt and BMP (Bone Morphogenetic Protein) signalling necessary for the development of most organs and the homeostasis of different adult tissues...

DOAJ Open Access (DOAJ) DOI: 10.1186/1749-8104-3-19

Structural Design, Synthesis and Antioxidant, Antileishmania, Anti-Inflammatory and Anticancer Activities of a Novel Quercetin Acetylated Derivative

Saul Vislei Simões da Silva, Orlando Maia Barboza, Jéssica Teles Souza, Érica Novaes Soares et al. • Molecules (2021)

Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water, extensive enzymatic metabolism and a reduced bioavailability limit its biopharmacological use. The aim of this study was to perform structural mod...

DOAJ Open Access (DOAJ) DOI: 10.3390/molecules26226923

Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures

Dylan G. Chitwood, Qinghua Wang, Kathryn Elliott, Aiyana Bullock et al. • BMC Biotechnology (2021)

Abstract Background As bioprocess intensification has increased over the last 30 years, yields from mammalian cell processes have increased from 10’s of milligrams to over 10’s of grams per liter. Most of these gains in productivity can be ...

DOAJ Open Access (DOAJ) DOI: 10.1186/s12896-020-00667-2

Beneficial Effects of Pomegranate Peel Extract and Probiotics on Pre-adipocyte Differentiation

Valeria Sorrenti, Cinzia Lucia Randazzo, Cinzia Caggia, Gabriele Ballistreri et al. • Frontiers in Microbiology (2019)

The beneficial effects of pomegranate are due to the ellagitannins and anthocyanins content, which are protective toward a wide variety of diseases including inflammatory diseases. Many investigators have reported that pomegranate waste (pe...

DOAJ Open Access (DOAJ) DOI: 10.3389/fmicb.2019.00660

Adaptation of SIVmac to baboon primary cells results in complete absence of in vivo baboon infectivity

Veronica Obregon-Perko, Amanda Mannino, Jason T. Ladner, Vida Hodara et al. • Frontiers in Cellular and Infection Microbiology (2024)

While simian immunodeficiency virus (SIV) infection is non-pathogenic in naturally infected African nonhuman primate hosts, experimental or accidental infection in rhesus macaques often leads to AIDS. Baboons, widely distributed throughout ...

DOAJ Open Access (DOAJ) DOI: 10.3389/fcimb.2024.1408245

Purification of Murine Gammaherpesvirus 68 With Use of Differential Centrifugation

Hodoši R., Nováková E., Šupolíková M. • European Pharmaceutical Journal (2021)

The method for separation of viral particles in a concentrated form from the environment is called virus purification. Viruses are required to be purified for a range of studies in which it is necessary to distinguish the properties or stru...

DOAJ Open Access (DOAJ) DOI: 10.2478/afpuc-2021-0009

Cadmium sulfide-induced toxicity in the cortex and cerebellum: In vitro and in vivo studies

Atefeh Varmazyari, Ali Taghizadehghalehjoughi, Cigdem Sevim, Ozlem Baris et al. • Toxicology Reports (2020)

Living organisms have an innate ability to regulate the synthesis of inorganic materials, such as bones and teeth in humans. Cadmium sulfide (CdS) can be utilized as a quantum dot that functions as a unique light-emitting semiconductor nano...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.toxrep.2020.04.011

Identification of Eusynstyelamide B as a Potent Cell Cycle Inhibitor Following the Generation and Screening of an Ascidian-Derived Extract Library Using a Real Time Cell Analyzer

Michelle S. Liberio, Martin C. Sadowski, Colleen C. Nelson, Rohan A. Davis • Marine Drugs (2014)

Ascidians are marine invertebrates that have been a source of numerous cytotoxic compounds. Of the first six marine-derived drugs that made anticancer clinical trials, three originated from ascidian specimens. In order to identify new anti-...

DOAJ Open Access (DOAJ) DOI: 10.3390/md12105222

Effect of Glycyrrhiza uralensis crude water extract on the expression of Nitric Oxide Synthase 2 gene during myogenesis

Afsha Fatima Qadri, Sibhghatulla Shaikh, Ye Chan Hwang, Khurshid Ahmad et al. • Heliyon (2024)

Glycyrrhiza uralensis is a traditional herbal medicine with significant bioactivity. This study investigated the effect of G. uralensis crude water extract (GU-CWE) on nitric oxide synthase 2 (NOS2) expression during myogenesis. GU-CWE trea...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.heliyon.2024.e34747

The niche-derived glial cell line-derived neurotrophic factor (GDNF) induces migration of mouse spermatogonial stem/progenitor cells.

Lisa Dovere, Stefania Fera, Margherita Grasso, Dante Lamberti et al. • PLoS ONE (2013)

In mammals, the biological activity of the stem/progenitor compartment sustains production of mature gametes through spermatogenesis. Spermatogonial stem cells and their progeny belong to the class of undifferentiated spermatogonia, a germ ...

DOAJ Open Access (DOAJ) DOI: 10.1371/journal.pone.0059431

Advances in Retinal Stem Cell Biology

Andrea S Viczian • Journal of Ophthalmic & Vision Research (2013)

Tremendous progress has been made in recent years to generate retinal cells from pluripotent cell sources. These advances provide hope for those suffering from blindness due to lost retinal cells. Understanding the intrinsic genetic network...

DOAJ Open Access (DOAJ)

Human RP105 monoclonal antibody enhances antigen-specific antibody production in unique culture conditions

Tatsuya Yamazaki, Kenta Iwasaki, Susumu Tomono, Masaki Imai et al. • iScience (2024)

Summary: Detecting antibodies, particularly those targeting donor human leukocyte antigens in organ transplantation and self-antigens in autoimmune diseases, is crucial for diagnosis and therapy. Radioprotective 105 (RP105), a Toll-like rec...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.isci.2024.110649

Efficacy and safety of biofilm dispersal by glycoside hydrolases in wounds

Whitni K. Redman, Garrett S. Welch, Avery C. Williams, Addyson J. Damron et al. • Biofilm (2021)

Novel anti-biofilm and dispersal agents are currently being investigated in an attempt to combat biofilm-associated wound infections. Glycoside hydrolases (GHs) are enzymes that hydrolyze the glycosidic bonds between sugars, such as those f...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.bioflm.2021.100061

Towards automated metaphase cell detection using foundation models: A SAM and DINO-based approach

M. Cihad Arslanoglu, Abdulkadir Albayrak, Huseyin Acar • Engineering Science and Technology, an International Journal (2026)

Karyotyping is a widely used laboratory technique to detect abnormalities in chromosomes. Karyotyping consists of many steps, including collecting samples, cell culturing and metaphase cell detection. Cytogeneticists examine all the images ...

DOAJ Open Access (DOAJ) DOI: 10.1016/j.jestch.2025.102262

A web-based artificial intelligence system for label-free virus classification and detection of cytopathic effects

Zeynep Akkutay-Yoldar, Mehmet Türkay Yoldar, Yiğit Burak Akkaş, Sibel Şurak et al. • Scientific Reports (2025)

Abstract Identifying viral replication within cells demands labor-intensive isolation methods, requiring specialized personnel and additional confirmatory tests. To facilitate this process, we developed an AI-powered automated system called...

DOAJ Open Access (DOAJ) DOI: 10.1038/s41598-025-89639-0