Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines
Overview & Synopsis
Key Points Transgenic mice expressing 3 human cytokines enable expansion of CMML cells with limited stem cell engraftment. The mutational profile of CMML cells that expand in mice mirrors that of patient monocytes.
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Document Information
| Document Title | Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines |
|---|---|
| Author / Organization | Yanyan Zhang, Liang He, Dorothée Selimoglu-Buet, Chloe Jego, Margot Morabito, Christophe Willekens, M'Boyba Khadija Diop, Patrick Gonin, Valérie Lapierre, Nathalie Droin, Éric Solary, Fawzia Louache |
| Subject & Discipline | Multidisciplinary Academic Open Research |
| Categories | Science & Mathematics |
| Publication Year | 2017 |
| License / Rights | Open Access / Creative Commons |
| Resource Verification | Listed PDF (Verification Pending) |
| Original Host Website |
HAL Open Science
(hal.science)
|
| File Format | application/pdf (Portable Document Format) |
| Language | EN |
| Catalog ID | DOC-163705 |
| Original Source Link | Visit Source Page on hal.science » |